Acetadote package insert. Nashville, TN: Cumberland Pharmaceuticals, Inc., December2008.
ACT investigators. Acetylcysteine for prevention of renal outcomes in patients undergoing coronary and peripheral vascular angiography. Main results from the randomized acetylcysteine for contrast-induced nephropathy trial (ACT). Circulation. 2011;124:1250–1259.
et al.: N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer. Am J Pathol. 2004;164:1683–1696.
et al.: Pharmacokinetics of intravenous N-acetylcysteine in pre-term new-born infants. Eur J Clin Pharmacol. 1999;55:645–650.
et al.: Prospective randomized study of N-acetylcysteine, fenoldopam, and saline for prevention of radiocontrast-induced nephropathy. Cathet Cardiovasc Intervent. 2002;57:279–283.
Anonymous. Death after N-acetylcysteine. Lancet. 1984;1:1421.
J: Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emerg Med J. 2002;19:594–595.
et al.: Beneficial effect of acetylcysteine on cisplatin nephrotoxicity in rats. J Appl Toxicol. 1993;13:189–198.
G: Neonatal paracetamol poisoning. Arch Dis Child Fetal Neonatal Ed. 1999;81:F78.
A: Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death. Ann Emerg Med. 2004;44:401–406.
M: Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med. 1998;31:710–715.
et al.: A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study. J Am Coll Cardiol. 2003;41:2114–2118.
W: N-acetylcysteine as an antidote in methylmercury poisoning. Environ Health Perspect. 1998;106:267–271.
et al.: Randomized, blinded, placebo-controlled clinical trials of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease. Spine. 2008;33:1397–1402.
et al.: Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds. Toxicol ApplPharmacol. 1986;83:142–147.
DD: Histamine secretion induced by N-acetyl cysteine
. Agents Actions.
MD: Adverse reactions to N-acetylcysteine. Hum Toxicol. 1984;3:393–398.
et al.: The promise of N-acetylcysteine in neuropsychiatry. Trends Pharmacol Sci. 2013;34:167–177.
et al.: A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2007;50:272–279.
R: N-acetylcysteine in acute hepatic failure (non-paracetamol-induced). Hepatogastroenterology. 2000;47:786–789.
S: Oral acetylcysteine does not protect renal function from moderate to high doses of intravenous radiographic contrast. Cathet Cardiovasc Intervent. 2003;58:336–341.
GR: Is the oral acetylcysteine protocol the best treatment for late-presenting acetaminophen poisoning?Clin Toxicol. 2009;54:615–616.
et al.: Anaphylactoid reaction to IV acetylcysteine associated with electrocardiographic abnormalities. Pharmacotherapy. 1992;26:22–25.
O: Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol. 1986;31:217–222.
et al.: Acetylcysteine and contrast agent-associated nephrotoxicity. J Am Coll Cardiol. 2002;40:298–303.
et al.: Effects of intraoperative N-acetylcysteine in orthotopic liver transplantation. Br J Anaesth. 1995;75:352–354.
EW: Intravenous N-acetylcysteine for children. Pediatr Emerg Care. 2004;20:649–650.
A: Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose. J Toxicol Clin Toxicol. 1999;37:753–757.
JR: Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation. Biochem Pharmacol. 1979;28:2841–2946.
P: N-Acetylcysteine adsorption by activated charcoal. Vet Hum Toxicol. 1980;22:392–394.
M: Utility of acetylcysteine in treatment poisonings and adverse drug reactions. Drug Saf. 2000;2:123–148.
JP: Paracetamol (acetaminophen) attenuates in vitro mast cell and peripheral blood mononucleocyte cell histamine release induced by N-acetylcysteine. Clin Toxicol. 2010;48:111–114.
et al.: Caring for the mother, concentrating on the fetus: intravenous N-acetylcysteine in pregnancy. Am J Emerg Med. 2008;6:735–738.
B: Patient tailored acetylcysteine administration. Ann Emerg Med. 2007;50:280–281.
J: Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust. 1989;150:329–331.
et al.: N-Acetylcysteine pretreatment of cardiac surgery patients influences plasma neutrophil elastase and neutrophil influx in bronchoalveolar lavage fluid. Intensive Care Med. 1996;22:900–908.
et al.: Chemopreventive properties and mechanisms of N-acetylcysteine. The experimental background. J Cell Biochem. 1995;22(suppl):33–41.
et al.: N-acetylcysteine improves indocyanine green extraction and oxygen transport during hepatic dysfunction. Crit Care Med. 1997;25:236–242.
DW: Acetylcysteine to prevent angiography-related renal tissue injury (The APART Trial). Am J Cardiol. 2002;89:356–358.
W: Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med. 2009;16:34–39.
BK: Stability and microbiology of inhalant N-acetylcysteine used as an intravenous solution for the treatment of acetaminophen poisoning. Ann Emerg Med. 2003;42:9–13.
B: New recommendation for N-acetylcysteine dosing may reduce incidence of adverse effects. Emerg Med J. 2006;23:584–585.
et al.: A randomized controlled trial of N-acetylcysteine to prevent contrast nephropathy in cardiac angiography. Kidney Int. 2002;62:2202–2207.
et al.: N-acetylcysteine for the treatment of clove oil-induced fulminant hepatic failure. Clin Toxicol. 2004;42:89–92.
et al.: The effect of activated charcoal on N-acetylcysteine absorption in normal subjects. Am J Emerg Med. 1987;5:483–487.
et al.: Treatment of amatoxin poisoning: 20-year retrospective analysis. Clin Toxicol. 2002;40:715–757.
TJ: Use of N-acetylcysteine in clinical toxicology. Am J Med. 1991;91:131S–139S.
AL: Australian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2006;47:124.
G: Anaphylactoid reaction to acetylcysteine. Clin Pharm. 1984;3:586–587.
et al.: Oral acetylcysteine as an adjunct to saline hydration for the prevention of contrast-induced nephropathy following coronary angiography. Eur Heart J. 2004;25:212–218.
et al.: A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med. 2007;5:32.
et al.: N-acetylcysteine administered as part of the immediate post-traumatic resuscitation regimen does not significantly influence initiation of inflammatory responses or subsequent endotoxin hyporesponsiveness. Resuscitation. 2005;64:377–382.
et al.: N-acetylcysteine as a novel prophylactic treatment for ifosfamide-induced nephrotoxicity in children: translational pharmacokinetics. J Clin Pharmacol. 2012;52:55–64.
et al.: Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet. 1990;335:1572–1573.
et al.: Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med. 1991;324:1852–1857.
S: Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose. Ann Pharmacotherapy. 2008;42:766–770.
K: A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose. Clin Toxicol. 2010;48:424–430.
TH: Massive acetylcysteine overdose associated with cerebral edema and seizures. Clin Toxicol. 2011;49:423–425.
S: N-acetylcysteine therapy of acute heavy metal poisoning in mice. Vet Human Toxicol. 1985;27:522–525.
JJ: Asthma associated with N-acetylcysteine infusion and paracetamol poisoning: report of two cases. Br Med J. 1983;287:876–877.
MR: Clinical pharmacokinetics of N-acetylcysteine. Clin Pharm. 1991;20:123–134.
et al.: Improvement in renal function in hepatorenal syndrome with N-acetylcysteine. Lancet. 1999;353:294–295.
RG, Pizarro-Osilla: Not so fast!Ann Emerg Med. 2006;47:122–123.
et al.: Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity. J Toxicol Clin Toxicol. 1997;35:447–451.
AB: The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand JClin Lab Invest. 1994;54:543–547.
G: Transfer of N-acetylcysteine by the human placenta. Vet Hum Toxicol. 1993;35:365.
et al.: Pharmacokinetics of N-acetylcysteine are altered in patients with chronic liver disease. Aliment Pharmacol Ther. 1997;11:787–791.
RB: What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?Ann Emerg Med. 2003;42:741–750.
et al.: In vitro toxicity test of poisonous mushroom extracts with isolated rat hepatocytes. J Toxicol Sci. 1990;15:145–156.
et al.: Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial. JAMA.[JAMA and JAMA Network Journals Full Text]
et al.: Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. Br Med J. 1991;303:1026–1029.
et al.: The Australasian clinical toxicology intervention collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45:402–409.
G: Adsorption of oral antidotes for acetaminophen poisoning (methionine and N-acetylcysteine) by activated charcoal. Clin Toxicol. 1981;18:283–290.
et al.: Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest. 1996;14:202–210.
et al.: Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. Liver Transplant. 2008;14:25–30.
et al.: N-acetylcysteine for the prevention of radiocontrast induced nephropathy: a meta-analysis of prospective controlled trials. J Am Soc Nephrol. 2004;15:761–769.
JR: Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats. J Clin Invest. 1983;71:980–991.
M: Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut. 1988;29:1153–1157.
et al.: Intravenous administration of N-acetylcysteine: oral and parenteral formulations are both acceptable. Ann Emerg Med. 2005;45:223–224.
HR: Neonatal paracetamol poisoning: treatment by exchange transfusion. Arch Dis Child. 1983;58:631–633.
et al.: Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. Gastroenterology. 2009;137:856–864.
W: Is there a “NAC” to treating acute liver failure. Liver Transplant. 2008;14:7–8.
BH: Acetaminophen overdose. Emerg Med Clin North Am. 1984;2:103–119.
JC: Antioxidant therapy in intensive care. Curr Opin Crit Care. 2003;9:266–270.
C: The administration of Nacetylcysteine causes a decrease in prothrombin time in patients with paracetamol overdose but without evidence of liver impairment. Eur J Gastroenterol Hepatol. 2005;17:59–63.
R: Anaphylactoid reactions to intravenous Nacetylcysteine: a prospective case controlled study. Accid Emerg Nurs. 2004;12:10–15.
AS: Effect of N-acetylcysteine on cardiac injury and oxidative stress after abdominal aortic aneurysm repair: a randomized controlled trial. Acta Anaesthiol Scand. 2011;55:1015–1021.
FK: The potential role of N-acetylcysteine for the treatment of Helicobacter pylori. J Clin Gastroenterol. 2011;45:841–843.
C: Intravenous loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2006;47:123.
JC: Adverse reactions to acetylcysteine and effects of overdose. Br Med J. 1984;289:217–219.
et al.: N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. N Engl J Med. 2006;354:2773–2882.
R: Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis. J Med Econ 2009;12:384–391.
EP: Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity. Clin Toxicol. 2010;48:79–83.
AM: How safe is intravenous N-acetylcysteine for the treatment of paracetamol poisoning. Hong Kong J Emerg Med. 2007;14:198–203.
JL: Antiemetic use in acetaminophen poisoning: how does the route of N-acetylcysteine administration affect utilization?J Med Toxicol. 2007;3:152–156.
et al.: Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Pharmacol Ther. 1974;16:676–684.
M: Acute renal dysfunction in acetaminophen poisoning. Renal Failure. 2005;27:381–383.
IV: Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. Clin Toxicol. 2011;49:755–759.
TB: What is the rate of adverse events with intravenous versus oral N-acetylcysteine in pediatric patients?Ann Emerg Med. 2004;44:547–548.
et al.: Multiple-dose pharmacokinetics and pharmacodynamics of N-acetylcysteine in patients with end-stage renal disease. Clin J Am Soc Nephrol. 2010;5:1588–1594.
E: Effect of activated charcoal administration on acetylcysteine serum levels in humans. Am J Hosp Pharm. 1981;38:1022–1024.
et al.: N-acetyulcysteine reduces oxidative stress in sickle cell patients. Ann Hematol. 2012;91:1097–1105.
et al.: Sodium bicarbonate, N-acetylcysteine, and saline for prevention of radiocontrast-induced nephropathy. A comparison of 3 regimens for protecting contrast-induced nephropathy in patients undergoing coronary procedures. A single-center prospective controlled trial. Am Heart J. 2007;154:539–544.
K: Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress. Exerc Immunol Rev. 2004;10:129–141.
PJ: Pharmacokinetic and pharmacodynamic studies of N-acetylcysteine, a potential chemopreventive agent during a phase 1 trial. Cancer Epidemiol Biomarkers Prev. 1995;4:245–251.
DA: Reversal of experimental paracetamol toxicosis with N-acetylcysteine. Lancet. 1976;2:738–739.
HE: The in vitro effect of N-acetylcysteine on prothrombin time in plasma samples from healthy subjects. Acad Emerg Med.
F: Adverse reaction from use of intravenous N-acetylcysteine. J Emerg Med. 2006;31:434–435.
et al.: Lack of toxicity after paracetamol overdose in a extremely preterm neonate. Eur J Clin Pharmacol. 2012;68:901–902.
et al.: Cysteamine
, methionine, and penicillamine in the treatment of paracetamol poisoning. Lancet.
et al.: The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol over-dosage. Eur J ClinPharmacol. 1989;37:501–506.
et al.: Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. Br Med J. 1979;2:1097–1100.
et al.: Successful treatment of severe paracetamol overdosage with cysteamine
L: Oral or intravenous N-acetylcysteine for acetaminophen poisoning?Ann Emerg Med. 2005;45:409–413.
et al.: N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med. 2000;28:3799–3807.
R: The effect of N-acetylcysteine cysteine
on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice. Cancer Res.
et al.: Concomitant use of activated charcoal and N-acetylcysteine. Ann Emerg Med. 1985;14:568–572.
BE: Respiratory arrest after N-acetylcysteine for a paracetamol overdose. Lancet. 1992;340:675.
et al.: Acute acetaminophen overdose during pregnancy. Obstet Gynecol. 1989;74:247–253.
et al.: Immunohistochemical localization and quantification of the 3 (cystein-5-yl) acetaminophen protein adduct in acetaminophen hepatotoxicity. Am J Pathol. 1991;138:359–371.
et al.: Paracetamol metabolites in the neonate following maternal overdose. Br J Clin Pharmacol. 1984;18:201–201.
M: Antioxidants specifically inhibit cisplatin cytotoxicity of human malignant glioma cells. Anticancer Res. 1998;18:4493–4498.
A: GSH rescue by N-acetylcysteine. Klin Wochenschr. 1991;69:857–862.
DN: Acetaminophen and acetylcysteine dose and duration: past, present, and future. Clin Toxicol. 2012;50:91–98.
BH: Acetaminophen toxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40:3–20.
RG: Acetaminophen overdose: incidence, diagnosis and management in 416 patients. Pediatrics. 1978;62(Suppl):898–903.
A: In vitro coadsorption of acetaminophen and N-acetylcysteine onto activated carbon powder. J Pharm Sci. 1986;75:904–905.
J: Acetylcysteine and nephrotoxic effects of radiographic contrast agents—a new use for an old drug. N Engl J Med. 2000;343:210–212.
H: Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology. 2010;51:246–254.
DN: Adverse reactions associated with acetylcysteine. Clin Toxicol. 2009;47:81–88.
et al.: Effects of N-acetylcysteine against systemic and renal hemodynamic effects of endotoxin in healthy humans. Crit Care Med. 2007;35:1869–1875.
KF: Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine
. Ann Emerg Med.
et al.: Transplacental transport of N-acetylcysteine in an ovine model. Ann Intern Med. 1991;20:1069–1072.
et al.: The dilemma of NAC therapy in a premature infant. J Toxicol Clin Toxicol. 2000;38:57.
D: Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N-acetylcysteine. Chem Commun. 2010;46:409–411.
SB: A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose. Clin Toxicol. 2011;49:643–647.
M: Severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine. Am J Med. 1992;93:94–96.
P: Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure. J Am Coll Cardiol. 2002;40:1383–1388.
SD: Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans. Clin Pharmacol Ther. 1987;41:413–418.
et al.: Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine protocol. Ann Emerg Med. 1991;20:1058–1063.
et al.: Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976–1985). N Engl J Med. 1988;319:1557–1562.
LS: Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy. Ann Pharmacother. 2008;42:1333–1339.
J: N-acetylcysteine in acute cardiology: 10 years later: what do we know and what would we like to know?J Am Coll Cardiol. 2002;39:1422–1428.
et al.: Infarct size limitation: acute N-acetylcysteine defense (ISLAND) trial. Start of the study. Int J Cardiol. 1995;49:181–182.
et al.: Effects of N-acetylcysteine on microalbuminuria and organ failure in acute severe sepsis: results of a pilot study. Chest. 2005;127:1413–1419.
et al.: Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients. Crit Care Med. 1994;22:1738–1746.
et al.: Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo controlled trial. Hepatology. 2013;57:1542–1549.
M: Effect of N-acetylcysteine on air trapping in COPD. A randomized placebo-controlled trial. Chest. 2009;136:381–386.
et al.: Intensive care of patients with acute liver failure: recommendations of the U.S. Acute Liver Failure Study Group.Crit Care Med. 2007;35:2498–2508.
N: Dilution of intravenous N-acetylcysteine as a cause of hyponatremia. Pediatrics. 1997;100:389–391.
et al.: N-acetylcysteine may prevent severe intestinal damage in necrotizing enterocolitis. J Ped Surg.
M, VanDer Giet
et al.: Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med. 2000;343:180–184.
et al.: The effect of N-acetylcysteine on posttraumatic changes after controlled cortical impact in rats. Intensive Care Med. 2006;32:149–155.
SD: Reactive intermediates in the oxidation of menthofuran by cytochromes P-450. Chem Res Toxicol. 1992;5:123–130.
SD: Menthofuran-dependent and independent aspects of pulegone hepatotoxicity: roles of glutathione. J Pharmacol Exp Ther. 1990;253:567–572.
RC: Comparative toxicity of eugenol and its quinine methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol. 1998;149:55–63.
et al.: Formation of glutathione conjugates during oxidation of eugenol by microsomal fractions of rat liver and lung. Biochem Pharmacol. 1990;39:1587–1595.
et al.: Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine
, thioctic acid, and silybin in a murine model. Ann Emerg Med.
et al.: N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography. Ann Emerg Med.
DC: Anaphylactoid reactions to N-acetylcysteine. Lancet. 1982;2:988.
EG, de Castro
JA: N-acetyl cysteine
is an early but also a late preventive agent against carbon tetrachloride-induced liver necrosis. Toxicol Lett.
A: N-Acetylcysteine administration in the critically ill. Intensive Care Med. 1999;25:432–434.
et al.: The effect of N-acetylcysteine on oxygen transport and uptake in patients with fulminant hepatic failure. Hepatology. 1998;27:1332–1340.
KM: Anaphylactoid reaction to N-acetylcysteine. Lancet. 1979;2:1298.
OD: Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose. Clin Toxicol. (Phila). 2008;46:496–500.
U: Intravenous administration of N-acetylcysteine: interference with coagulopathy testing. Ann Emerg Med. 2004;44:546–547.
AH: Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database. Curr Med Res Opin. 2007;23:2359–2368.
et al.: Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma. Melanoma Res. 2003;13:189–196.
et al.: Shorter duration of oral Nacetylcysteine therapy for acute acetaminophen overdose. Ann Emerg Med. 2000;35:363–368.
et al.: Prolonged treatment with N-acetylcysteine delays liver recovery from acetaminophen hepatotoxicity. Crit Care. 2009;13:R55.
et al.: IV versus oral N-acetylcysteine. Ann Emerg Med. 2010;55:394–395.
et al.: Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 2009;54:606–614.
AS: Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine. J Neurotrauma. 2006;23:86–96.
K: Intravenous administration of oral N-acetylcysteine. CritCare Med. 1998;26:40–43.
RC: A 20-hour treatment for acute acetaminophen overdose. N Engl J Med. 2003;348:2471–2472.
et al.: Incidence of adverse drug reactions induced by N-acetylcysteine in patients with acetaminophen overdose. Hum Exper Toxicol. 2010;29:153–160.
SW: Effects of delay in infusion of N-acetylcysteine on appearance of adverse drug reactions after acetaminophen overdose: a retrospective study. Pharmacoepidemiol Drug Saf. 2010;19:1064–1070.