Cocaine toxicity is likely in a patient who exhibits signs and symptoms consistent with sympathomimetic stimulation. Occasionally, the sympathomimetic toxidrome is difficult to distinguish from that caused by anticholinergic toxicity. Both toxidromes are associated with CNS excitation, mydriasis, tachycardia, hypertension, and hyperthermia. Unlike sympathomimetic toxicity, however, anticholinergics will cause urinary retention and decreased bowel sounds. Also, sympathomimetic toxicity is often associated with diaphoresis, while anticholinergic overdose is associated with dry skin.