The anatomic location of the injury helps predict the clinical outcome, both in terms of infection risk and cosmetic result7,8,15,20 (Table 37-3). The risk of infection is determined largely by the interplay between baseline bacterial colonization and vascular blood supply. With respect to bacterial colonization, the density of the bacterial population is low on the upper arms, legs, and torso. Conversely, moist areas of the body, such as the axilla, perineum, toe webs, and intertriginous areas, harbor millions of bacteria per square centimeter, including anaerobes. Obviously, any wounds with human or animal fecal contaminants run a high risk of infection, even with therapeutic intervention.