TY - CHAP M1 - Book, Section TI - Adrenal Insufficiency A1 - Marcolini, Evie G. A1 - Chiu, William C. A2 - Farcy, David A. A2 - Chiu, William C. A2 - Marshall, John P. A2 - Osborn, Tiffany M. Y1 - 2016 N1 - T2 - Critical Care Emergency Medicine, 2e AB - Adrenal gland function has provided great academic material for investigation and controversy. It was not until 1937 that 17-hydroxy-11-dehydrocorticosterone, or cortisone, was isolated by Reichstein from the adrenal cortex. By 1947, synthetic cortisone was developed. At the same time, in addition to the use of cortisone for Addison disease, this compound was found to have a therapeutic effect in patients with rheumatoid pain through its ability to inhibit stress and inflammation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1135702711 ER -