TY - CHAP M1 - Book, Section TI - Autotransfusion A1 - Roldan, Carlos J. A1 - Mehta, Amit A2 - Reichman, Eric F. Y1 - 2018 N1 - T2 - Reichman's Emergency Medicine Procedures, 3e AB - Trauma is the leading cause of death in children and adults under 44 years of age.1 Exsanguination plays a significant role in as many as half of these deaths, with hemorrhagic shock the most common cause for potentially preventable death.2 Hemorrhagic shock is a primary indication for the transfusion of homologous blood products. Transfusions with homologous blood products carry the possibility of associated complications including transfusion reactions, transmission of infectious diseases, and sensitization to antigens.3 Massive transfusions are associated with the additional complications of acidosis, dilutional coagulopathy, and hypothermia. Transfusion of homologous blood products in the trauma patient has been independently associated with an increase in both morbidity and mortality, particularly when transfusing older stored blood products.4-6 Blood centers have more than doubled the prices of blood products in recent years due to a decline in blood donors, higher skilled labor costs, and increases in the cost of testing and processing blood.7 There is evidence that the best replacement for whole blood loss may be fresh whole blood.8 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1159811132 ER -