RT Book, Section
A1 Rella, Joseph G.
A1 Carter, Wallace A.
A2 Tintinalli, Judith E.
A2 Stapczynski, J. Stephan
A2 Ma, O. John
A2 Yealy, Donald M.
A2 Meckler, Garth D.
A2 Cline, David M.
SR Print(0)
ID 1121499880
T1 Nonsteroidal Anti-Inflammatory Drugs
T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071794763
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1121499880
RD 2024/04/19
AB Nonsteroidal  anti-inflammatory  drugs  (NSAIDs)  are  among  the  most  widely  used  class  of  drugs  in  the  United  States,  and  all  share  inhibition  of  the  cyclooxygenase  enzyme  as  a  mechanism  of  action.  NSAIDs  are  effective  antipyretics,  analgesics,  and  anti-inflammatory  agents.  Because  of  their  large  therapeutic  window,  acute  ingestion  with  overdoses  rarely  produces  serious  complications.1,2  The  morbidity  from  NSAIDs  in  acute  overdose  is  far  overshadowed  by  complications  of  NSAIDs  at  therapeutic  doses,  which  include  GI  bleeding,  drug-induced  renal  failure,  and  atherosclerotic  heart  disease.3,4,5,6  Due  to  their  increased  risk  for  cardiovascular  disease,  rofecoxib  and  valdecoxib  were  withdrawn  from  the  U.S.  market  in  2004  and  2005,  respectively.