RT Book, Section
A1 Wolff, Klaus
A1 Johnson, Richard Allen
A1 Saavedra, Arturo P.
A1 Roh, Ellen K.
SR Print(0)
ID 1140789521
T1 NEUTROPHIL-MEDIATED DISEASES
T2 Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology, 8e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259642197
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1140789521
RD 2024/04/25
AB PG  is  an  idiopathic,  either  acute  or  chronic,  severely  debilitating  skin  disease.It  is  characterized  by  neutrophilic  infiltration,  destruction  of  tissue,  and  ulceration.It  occurs  most  commonly  in  association  with  a  systemic  disease,  especially  arthritis,  inflammatory  bowel  disease,  hematologic  dyscrasias,  and  malignancy,  but  may  also  occur  alone.Characterized  by  the  presence  of  painful,  irregular,  boggy,  blue-red  ulcers  with  undermined  borders  and  purulent  necrotic  bases.There  is  no  laboratory  test  that  establishes  the  diagnosis.The  mainstays  of  treatment  are  immune-suppressive  or  -modulating  agents.Relapses  occur  in  most  patients  and  there  is  significant  morbidity.