RT Book, Section A1 Yin, Shan A2 Cydulka, Rita K. A2 Fitch, Michael T. A2 Joing, Scott A. A2 Wang, Vincent J. A2 Cline, David M. A2 Ma, O. John SR Print(0) ID 1143142684 T1 Psychopharmacologic Agents T2 Tintinalli's Emergency Medicine Manual, 8e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071837026 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1143142684 RD 2024/04/25 AB Cyclic antidepressants inhibit reuptake of norepinephrine and serotonin, block sodium channels, and antagonize postsynaptic serotonin receptors. They can produce severe toxicity in overdose. Their use has declined as newer, safer agents have been developed.