RT Book, Section
A1 Gentges, Joshua
A2 Cline, David M.
A2 Ma, O. John
A2 Cydulka, Rita K.
A2 Meckler, Garth D.
A2 Handel, Daniel A.
A2 Thomas, Stephen H.
SR Print(0)
ID 56273162
T1 Chapter 48. Jaundice, Hepatic Disorders, and Hepatic Failure
T2 Tintinalli's Emergency Medicine Manual, 7e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-178184-8
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=56273162
RD 2024/04/23
AB Jaundice,  a  yellowish  discoloration  of  the  skin,  sclerae,  and  mucous  membranes,  results  from  hyperbilirubinemia  (breakdown  of  hemoglobin)  and  the  deposition  of  bile  pigments.  Etiologies  include  disorders  of  bilirubin  metabolism  (eg,  hemolysis)  and  hepatocellular  causes  due  to  infections,  drugs  and  toxins,  metabolic  disease,  granulomatous  disease,  and  bile  duct  obstruction.  Hyperbilirubinemia  can  be  divided  into  2  types.  The  unconjugated  form  results  from  increased  bilirubin  production  or  a  liver  defect  in  its  uptake  or  conjugation.  The  conjugated  form  occurs  in  the  setting  of  intra-  or  extrahepatic  cholestasis,  resulting  in  decreased  excretion  of  conjugated  bilirubin.