RT Book, Section
A1 Lu, Jenny J.
A2 Sherman, Scott C.
A2 Weber, Joseph M.
A2 Schindlbeck, Michael A.
A2 Rahul G., Patwari
SR Print(0)
ID 1101225847
T1 Acetaminophen Toxicity
T2 Clinical Emergency Medicine
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179460-2
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1101225847
RD 2024/04/23
AB Acetaminophen  is  the  most  popular  over-the-counter  analgesic  in  the  United  States  and  is  widely  prescribed  in  combination  form  with  alternative  pain  relievers,  resulting  in  frequent  unintentional  overdose.Treatment  with  N-acetylcysteine  detoxifies  NAPQI,  the  hepatotoxic  byproduct  of  acetaminophen  metabolism.The  Rumack-Matthew  nomogram  should  only  be  used  in  acute  overdoses  with  reliable  times  of  ingestion.  Pay  careful  attention  to  all  units  of  measurement.Consider  early  transfer  to  a  liver  transplant  center  for  patients  with  worsening  hepatic  function  or  general  signs  of  deterioration  before  they  meet  criteria  for  liver  transplantation.