RT Book, Section
A1 Lapoint, Jeff M.
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108432541
T1 Cannabinoids
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1108432541
RD 2024/04/19
AB Cannabis  has  been  used  for  more  than  4000  years.  The  earliest  documentation  of  the  therapeutic  use  of  marijuana  is  the  fourth  century  b.c.  in  China.156  Cannabis  use  spread  from  China  to  India  to  North  Africa,  reaching  Europe  around  a.d.  500.126  In  colonial  North  America,  cannabis  was  cultivated  as  a  source  of  fiber.  Like  cocaine  and  morphine,  cannabis  was  the  focus  of  research  efforts  in  the  19th  century.  Although  the  active  chemical  constituents  of  the  former  were  isolated  during  this  time,  that  of  cannabis  remained  elusive.91  This  is  due  to  the  fact  that  the  active  compounds  of  morphine  and  cocaine  are  both  alkaloids  and  were  possible  to  extract  with  the  technological  means  of  the  time,  whereas  the  methods  to  isolate  the  active  terpenes  in  cannabis  were  not  available  to  researchers  until  several  decades  later.