RT Book, Section A1 Thompson, Trevonne M. A1 Erickson, Timothy B. A2 Schafermeyer, Robert A2 Tenenbein, Milton A2 Macias, Charles G. A2 Sharieff, Ghazala Q. A2 Yamamoto, Loren G. SR Print(0) ID 1105686483 T1 Opioids T2 Strange and Schafermeyer's Pediatric Emergency Medicine, 4e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-182926-7 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1105686483 RD 2024/04/19 AB The classical triad of central nervous system depression, respiratory depression, and pinpoint pupils characterizes opioid toxicity.Some opioids, such as methadone can have delayed or prolonged effects.Opioids can cause acute lung injury or noncardiogenic pulmonary edema in severe overdoses.Toxicity from propoxyphene, meperidine, and tramadol, as well as neonatal opioid withdrawal, can result in seizure activity.Airway management and the use of the pure opioid antagonist naloxone are the mainstays of opioid toxicity treatment.