This patient has characteristics suggestive of severe sepsis. Source control is a key component of successful therapy in sepsis. Definitive treatment of sepsis would be removal of the nidus of infection if feasible. Patients receiving dialysis through temporary external catheters are at higher risk for bacteremia than those with AV fistulas. Coagulase-negative staphylococcus and S. aureus comprise the majority of infections. Enterococcus and enteric gram-negative organisms must also be considered. While this patient should receive fluid resuscitation and antimicrobial therapy, this patient is unlikely to recover without removal of the source of infection. It would be prudent to assess this patient’s chemistry panel, but it is more likely that he is suffering from sepsis than dialyzable conditions such as uremia or hyperkalemia.