Oral lesions are common but rarely become secondarily infected.
Ocular involvement is exceedingly rare.
It often is complicated by thrombophlebitis.
Women may complain of vulvovaginitis.
Discomfort may be severe but fatalities are virtually unheard of.
The Stevens-Johnson syndrome is a severe form of erythema multiforme characterized by generalized bullae that involve the skin and mucous membranes, including the mouth, vagina, eyes, and esophagus. Dehydration results from painful stomatitis and weeping skin surfaces. Secondary infections of the denuded epithelium are common, as are severe ocular complications, including corneal ulcers and blindness. Thrombophlebitis is not particularly associated with the disease. Steroids provide symptomatic relief. The overall mortality is 5–10%.