Mucocutaneous Signs of Systemic Cancers
ICD-9: 199.0 ○ ICD-10: M8000/6
Classification of Skin Signs of Systemic Cancer
Lymphatic extension, hematogenous spread.1
Paget disease, extramammary Paget disease.
Lymphomas with secondary skin involvement (Section 21).
Multiple endocrine neoplasia (types 1 and 2b).
Acanthosis nigricans, malignant, tripe palms.
Metastatic Cancer to the Skin
ICD-9: 199.0 ○ ICD-10: M8000/6*
Metastatic cancer to the skin is characterized by solitary or multiple dermal or subcutaneous nodules, occurring as metastatic cells from a distant noncontiguous primary malignant neoplasm.
They are transported to and deposited in the skin or subcutaneous tissue by one of the following routes:
Skin lesions nodule (Figs. 19-1 and 19-2), raised plaque, thickened fibrotic area. First detected when <5 mm. Fibrotic area may resemble morphea; occurring on scalp, may produce alopecia. Initially, epidermis is intact, stretched over nodule; in time, surface may become ulcerated (Fig. 19-3) or hyperkeratotic. May appear inflammatory, i.e., pink to red or hemorrhagic. Firm to indurated. May be solitary, few, or multiple. May acquire considerable size and may be mistaken for a primary skin cancer (Fig. 19-3).
Metastatic cancer to the skin: bronchogenic cancer Dermal nodules on the scalp of a patient undergoing chemotherapy for metastatic lung cancer; the nodules were only apparent following loss of hair during chemotherapy. The nodule on the left is asymptomatic, erythematous, ...