Skip to Main Content

We have a new app!

Take the Access library with you wherever you go—easy access to books, videos, images, podcasts, personalized features, and more.

Download the Access App here: iOS and Android



The first-generation (typical) antipsychotics, introduced in the 1950s, were effective against the positive features of psychosis (e.g., delusions, hallucinations, disorganized thought) but provided no treatment for the negative features (e.g., avolition, alogia, social withdrawal). In addition, numerous adverse side effects associated with these agents led to poor patient compliance. The second-generation (atypical) antipsychotics were introduced in the 1990s, and the third generation followed in the 2000s. These second- and third-generation drugs work on both the positive and negative symptoms and, when taken at therapeutic doses, are associated with fewer extrapyramidal effects than the first-generation antipsychotics (Table 180-1).

TABLE 180-1Common Antipsychotics

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.