Roth spots are retinal hemorrhages with a white or yellow center. They may be seen in patients with a host of diseases such as anemia, leukemia, multiple myeloma, diabetes mellitus, collagen vascular disease, other vascular diseases, intracranial hemorrhage in infants, septic retinitis, and carcinoma. Flame-shaped or splinter hemorrhages or dot-blot hemorrhages may resemble Roth spots.
Management and Disposition
Routine referral for general medical evaluation is appropriate.
Roth spots are not pathognomonic for any particular disease process and can represent a variety of clinical conditions.
These lesions represent red blood cells surrounding inflammatory cells.
Roth Spots. Multiple retinal hemorrhages with pale centers are seen. (Photo contributor: Tal Rubinstein, MD.)
Roth Spot. Retinal hemorrhage with pale center. (Photo contributor: William E. Cappaert, MD.)