MUCOCUTANEOUS SIGNS OF SYSTEMIC CANCERS ICD-10: M8000/6
Mucocutaneous findings may suggest systemic cancers in several ways:
Associations of heritable mucocutaneous disorders with systemic cancers.
By action at a distance, i.e., paraneoplastic syndromes.
Or spread of cancer to the skin or mucosal sites by direct, lymphatic, or hematogenous extension (cutaneous metastasis).
CLASSIFICATION OF SKIN SIGNS OF SYSTEMIC CANCER
PERSISTENT TUMOR Lymphatic extension and hematogenous spread.
DIRECT EXTENSION Paget disease and extramammary Paget disease.
Lymphomas with secondary skin involvement (Section 21).
Multiple endocrine neoplasia (types 1 and 2b)
Acanthosis Nigricans, Malignant, Tripe Palms
Paraneoplastic Pemphigus (paraneoplastic autoimmune multiorgan syndrome)
METASTATIC CANCER TO THE SKIN ICD-10: M8000/6
Metastatic cancer to the skin is characterized by solitary or multiple dermal or subcutaneous nodules, occurring as metastatic cells from a distant noncontiguous primary malignant neoplasm1.
They are transported to and deposited in the skin or subcutaneous tissue by one of the following routes:
Skin lesions nodules (Figs. 19-1 and 19-2), raised plaque, thickened fibrotic area. The fibrotic area may resemble morphea; occurring on scalp, may produce alopecia. Initially, epidermis is intact and stretched over nodule; in time, the surface may become friable, eroded (Fig. 19-3), or hyperkeratotic. It may appear inflammatory, i.e., pink to red or hemorrhagic. Firm to indurated. May be solitary, few, or multiple. May acquire considerable size and may be mistaken for a primary skin cancer (Fig. 19-3).
Metastatic cancer to the skin: bronchogenic cancer Dermal nodules on the neck of a patient undergoing chemotherapy for metastatic lung cancer. These were asymptomatic, erythematous, but noninflamed. (Used with permission of Dr. Barbara Wilson.)