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MUCOCUTANEOUS SIGNS OF SYSTEMIC CANCERS ICD-10: M8000/6
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Mucocutaneous findings may suggest systemic cancers in several ways:
Associations of heritable mucocutaneous disorders with systemic cancers.
By action at a distance, i.e., paraneoplastic syndromes.
Or spread of cancer to the skin or mucosal sites by direct, lymphatic, or hematogenous extension (cutaneous metastasis).
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CLASSIFICATION OF SKIN SIGNS OF SYSTEMIC CANCER
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PERSISTENT TUMOR Lymphatic extension and hematogenous spread.
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DIRECT EXTENSION Paget disease and extramammary Paget disease.
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Lymphomas with secondary skin involvement (Section 21).
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Birt–Hogg–Dube Syndrome
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Multiple endocrine neoplasia (types 1 and 2b)
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Peutz–Jeghers Syndrome
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PARANEOPLASTIC SYNDROMES
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Acanthosis Nigricans, Malignant, Tripe Palms
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Paraneoplastic Pemphigus (paraneoplastic autoimmune multiorgan syndrome)
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METASTATIC CANCER TO THE SKIN ICD-10: M8000/6
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Metastatic cancer to the skin is characterized by solitary or multiple dermal or subcutaneous nodules, occurring as metastatic cells from a distant noncontiguous primary malignant neoplasm1.
They are transported to and deposited in the skin or subcutaneous tissue by one of the following routes:
Skin lesions nodules (Figs. 19-1 and 19-2), raised plaque, thickened fibrotic area. The fibrotic area may resemble morphea; occurring on scalp, may produce alopecia. Initially, epidermis is intact and stretched over nodule; in time, the surface may become friable, eroded (Fig. 19-3), or hyperkeratotic. It may appear inflammatory, i.e., pink to red or hemorrhagic. Firm to indurated. May be solitary, few, or multiple. May acquire considerable size and may be mistaken for a primary skin cancer (Fig. 19-3).
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