Skip to Main Content

MUCOCUTANEOUS SIGNS OF SYSTEMIC CANCERS ICD-10: M8000/6

  • Mucocutaneous findings may suggest systemic cancers in several ways:

    • Associations of heritable mucocutaneous disorders with systemic cancers.

    • By action at a distance, i.e., paraneoplastic syndromes.

  • Or spread of cancer to the skin or mucosal sites by direct, lymphatic, or hematogenous extension (cutaneous metastasis).

CLASSIFICATION OF SKIN SIGNS OF SYSTEMIC CANCER

METASTATIC CANCERS

PERSISTENT TUMOR Lymphatic extension and hematogenous spread.

DIRECT EXTENSION Paget disease and extramammary Paget disease.

Lymphomas with secondary skin involvement (Section 21).

HERITABLE DISORDERS

Birt–Hogg–Dube Syndrome

 

Cowden Syndrome

 

Gardner syndrome

 

Muir–Torre syndrome

 

Multiple endocrine neoplasia (types 1 and 2b)

 

Neurofibromatosis

(see Section 16).

Peutz–Jeghers Syndrome

 

Tuberous sclerosis

(see Section 16).

PARANEOPLASTIC SYNDROMES

Acanthosis Nigricans, Malignant, Tripe Palms

  • Acquired ichthyosis

  • Bazex syndrome

  • Carcinoid syndrome

  • Dermatomyositis (see Section 14)

  • Ectopic ACTH syndrome

  • Erythema gyratum repens

Glucagonoma Syndrome

  • Hypertrichosis lanuginosa

  • Hypertrophic osteoarthropathy and digital clubbing

  • Palmar keratoses

Paraneoplastic Pemphigus (paraneoplastic autoimmune multiorgan syndrome)

METASTATIC CANCER TO THE SKIN ICD-10: M8000/6

  • Metastatic cancer to the skin is characterized by solitary or multiple dermal or subcutaneous nodules, occurring as metastatic cells from a distant noncontiguous primary malignant neoplasm1.

  • They are transported to and deposited in the skin or subcutaneous tissue by one of the following routes:

    • Lymphatic routes.

    • Hematogenous spread.

    • Contiguous spread across the peritoneal cavity or other tissues.

  • Skin lesions nodules (Figs. 19-1 and 19-2), raised plaque, thickened fibrotic area. The fibrotic area may resemble morphea; occurring on scalp, may produce alopecia. Initially, epidermis is intact and stretched over nodule; in time, the surface may become friable, eroded (Fig. 19-3), or hyperkeratotic. It may appear inflammatory, i.e., pink to red or hemorrhagic. Firm to indurated. May be solitary, few, or multiple. May acquire considerable size and may be mistaken for a primary skin cancer (Fig. 19-3).

FIGURE 19-1

Metastatic cancer to the skin: bronchogenic cancer Dermal nodules on the neck of a patient undergoing chemotherapy for metastatic lung cancer. These were asymptomatic, erythematous, but noninflamed. (Used with permission of Dr. Barbara Wilson.)

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.

  • Create a Free Profile