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Dyspnea is the uncomfortable awareness of difficult, labored, or unpleasant breathing. Normal resting patients are unaware of the act of breathing. For most patients presenting with dyspnea, there is either a cardiac or pulmonary cause of their symptoms (Table 10.1). Other, less common, causes include psychogenic factors, gastroesophageal reflux disease (GERD), and deconditioning.
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Look for signs of impending respiratory failure (severe tachypnea, tachycardia, stridor, agitation) and evidence for underlying etiology (eg, rash and hypotension with anaphylaxis).
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Conduct a systematic diagnostic and therapeutic evaluation for the cause of dyspnea.
Obtain a chest x-ray (CXR) at minimum. Obtain other studies (CT-PE, echocardiogram) based on clinical suspicion.
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Treat underlying condition.
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Cough results from stimulation of irritant receptors in the larynx, trachea, and major bronchi. Triggers include mucus, allergens, chemical irritants, gastric acid, and others. Likely etiologies differ depending on whether the cough is acute (< 3 weeks) or more persistent.
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Acute upper respiratory infection (pertussis, rhinitis, sinusitis)
Lower respiratory infection
Asthma/COPD (chronic obstructive pulmonary disease) exacerbation
Environmental irritants, such as pets, dust, and other allergens
Airway foreign body
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Smoking: Chemical irritant, chronic bronchitis
Postinfectious postnasal drip
GERD
Chronic asthma/COPD
Angiotensin-converting-enzyme (ACE) inhibitor
Bordetella pertussis
Other causes: Bronchiectasis, congestive heart failure (CHF), environmental irritants, and recurrent aspiration
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Inquire about postnasal drip symptoms, asthma, GERD, treatment with ACE inhibitors or angiotensin receptor blockers (ARBs), and smoking.
Determine if cough is productive (infection, bronchiectasis) or bloody (malignancy, infection, Goodpasture syndrome, Wegener granulomatosis).
The physical examination should focus on the nasal mucosa, lungs, heart, and extremities (for clubbing).
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KEY FACT
DDx of Clubbing
Interstitial lung disease
Chronic lung infections
Lung malignancy
Pulmonary arteriovenous malformation (AVM)
Cyanotic congenital heart disease
Infective endocarditis
Cirrhosis
Inflammatory bowel disease
Hyperthyroidism
Idiopathic
Hereditary
...