Insulin-euglycemia therapy for drug-induced shock was first reported in 1999.39 This case series included four patients who overdosed on verapamil and one with combined amlodipine-atenolol overdose. All failed traditional antidote therapy, but responded to rescue insulin therapy. Since the initial case series, the author's institution has treated six additional patients with rescue insulin therapy following inadequate response to standard antidotes, five of the six with good outcome. Sixty-seven cases appear in the literature that were treated at other institutions.2,3,5,10-13,16,25-29,31,33,34,36-38 Thus, there is an aggregate of 78 cases in which insulin was used. Of these cases, 72 primarily involved CCBs, five combined CCBs-BAAs, and one BAA. Various regimens of standard antidotes were used prior to insulin therapy and no case received insulin alone. Although no direct outcome comparisons can be made between insulin and standard therapies in these 78 cases, overall survival was 88% when insulin was included in resuscitation. Further review of these cases yields important clinical information that can be used to guide insulin therapy.