Historical clues to suggest a patient may be at risk for rhabdomyolysis include the following: injuries that can cause compartment syndrome or prolonged muscular compression, including traumatic crush injuries, acutely casted long-bone fractures, heat stroke, electrical injuries, and lightning strikes; prolonged immobilization; drug intoxication with numerous agents including amphetamines, phencyclidine (PCP), cocaine, or antihistamines; excessive muscular activity, seizures, dystonia, or delirium tremens; and diseases such as dermatomyositis, polymyositis, or neuroleptic malignant syndrome. Commonly prescribed medications associated with the development of rhabdomyolysis include antipsychotics, lipid-lowering agents (ie, statins and clofibrate), narcotics, zidovudine, and colchicine.