There are 3 age-based clinical presentations for pediatric UTIs. Neonates present with a clinical presentation indistinguishable from that of sepsis, and they may have symptoms that include fever, jaundice, poor feeding, irritability, and lethargy. Older infants and young children typically present with gastrointestinal complaints that may include fever, abdominal pain, vomiting, and a change in appetite. School-age children and adolescents typically present with adult-type complaints such as dysuria, urinary frequency, urgency, and hesitancy. Although the majority of infants and young children with fever and UTI have upper-track disease and require long-course antibiotic treatment, older children and adolescents without fever, flank pain, and flank tenderness are likely to have simple cystitis and can be treated with shorter course therapy similar to adults.