For TSS and STSS, fever and hypotension with associated erythroderma should suggest the diagnosis. The differential diagnosis is broad and includes scarlet fever, Rocky Mountain spotted fever, leptospirosis, rubeola, meningococcemia, SSSS, Kawasaki disease, TEN, Stevens-Johnson syndrome, gram-negative sepsis, and exfoliative drug eruptions. Infants and toddlers with fever and diffuse erythroderma suggest SSSS. The differential diagnosis for SSSS includes TEN, TSS, exfoliative drug eruptions, staphylococcal scarlet fever, and localized bullous impetigo.