1. O'Grady NP, Barie PS, Bartlett JG, et al. Practice guidelines for evaluating new fever in critically ill adult patients. Task Force of the Society of Critical Care Medicine and the Infectious Diseases Society of America. Clin Infect Dis. 1998;26(5):1042–1059.
2. Arons MM, Wheeler AP, Bernard GR, et al. Effects of
ibuprofen on the physiology and survival of hypothermic sepsis.
Ibuprofen in Sepsis Study Group.
Crit Care Med. 1999;27(4):699–707.
3. Circiumaru B, Baldock G, Cohen J. A prospective study of fever in the intensive care unit. Intensive Care Med. 1999;25(7):668–673.
4. Laupland KB, Shahpori R, Kirkpatrick AW, Ross T, Gregson DB, Stelfox HT. Occurrence and outcome of fever in critically ill adults. Crit Care Med. 2008;36(5):1531–1535.
5. Badjatia N. Fever control in the neuro-ICU: why, who, and when? Curr Opin Crit Care. 2009;15(2):79–82.
6. Brady JE, Sun LS, Rosenberg H, Li G. Prevalence of malignant hyperthermia due to anesthesia in New York State, 2001–2005. Anesth Analg. 2009;109(4):1162–1166.
7. Barbour HG. Die Wirkung unmittelbärer Erwärmung und Abkülung der Wärmezentra auf die Körpertemperature. Arch Exp Pathol Pharmakol. 1912;70(1):1–36.
8. Hammel HT, Hardy JD, Fusco MM. Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am J Physiol. 1960;198:481–486.
9. Hammel HT, Jackson DC, Stolwijk JA, Hardy JD, Stromme SB. Temperature regulation by hypothalamic proportional control with an adjustable set point. J Appl Physiol. 1963;18:1146–1154.
10. Hellstrom B, Hammel HT. Some characteristics of temperature regulation in the unanesthetized dog. Am J Physiol. 1967;213(2):547–556.
11. Dentener MA, Bazil V, Von Asmuth EJ, Ceska M, Buurman WA. Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages. J Immunol. 1993 1;150(7):2885–2891.
12. Dinarello CA, Cannon JG, Wolff SM. New concepts on the pathogenesis of fever. Rev Infect Dis. 1988;10(1):168–189.
13. Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J. 1994;8(15):1314–1325.
14. Murphy PA, Simon PL, Willoughby WF. Endogenous pyrogens made by rabbit peritoneal exudate cells are identical with lymphocyte-activating factors made by rabbit alveolar macrophages. J Immunol. 1980;124(5):2498–2501.
15. Stitt JT, Shimada SG. Calcium channel blockers inhibit endogenous pyrogen fever in rats and rabbits. J Appl Physiol. 1991;71(3):951–955.
16. Tarlow JK, Blakemore AI, Lennard A, et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet. 1993;91(4):403–404.
17. Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T. Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice. J Exp Med. 1996 1;183(1):311–316.
18. Kozak W, Kluger MJ, Soszynski D, et al. IL-6 and IL-1 beta in fever. Studies using cytokine-deficient (knockout) mice. Ann N Y Acad Sci. 1998;856:33–47.
19. Cao C, Matsumura K, Ozaki M, Watanabe Y. Lipopolysaccharide injected into the cerebral ventricle evokes fever through induction of cyclooxygenase-2 in brain endothelial cells. J Neurosci. 1999;19(2):716–725.
20. Buller KM. Role of circumventricular organs in pro–inflammatory cytokine-induced activation of the hypothalamic–pituitary–adrenal axis. Clin Exp Pharmacol Physiol. 2001;28(7):581–589.
21. Saper CB, Breder CD. Endogenous pyrogens in the CNS: role in the febrile response. Prog Brain Res. 1992;93:419–428. Discussion 28–29.
22. Mallick BN, Jha SK, Islam F. Presence of alpha-1 adrenoreceptors on thermosensitive neurons in the medial preoptico-anterior hypothalamic area in rats. Neuropharmacology. 2002;42(5):697–705.
23. Mitchell JD, Grocott HP, Phillips-Bute B, Mathew JP, Newman MF, Bar-Yosef S. Cytokine secretion after cardiac surgery and its relationship to postoperative fever. Cytokine. 2007;38(1):37–42.
24. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol. 1991;147(11):3815–3822.
25. Leon LR. Invited review: cytokine regulation of fever: studies using gene knockout mice. J Appl Physiol. 2002;92(6):2648–2655.
26. Rabinowitz RP, Cookson ST, Wasserman SS, Mackowiak PA. Effects of anatomic site, oral stimulation, and body position on estimates of body temperature. Arch Intern Med. 1996;156(7):777–780.
27. Kistemaker JA, Den Hartog EA, Daanen HA. Reliability of an infrared forehead skin thermometer for core temperature measurements. J Med Eng Technol. 2006;30(4):252–261.
28. Kiekkas P, Filos KS, Karanikolas M, Aretha D, Baltopoulos GI. Relationships between fever and outcome in intensive care unit patients. Crit Care Med. 2008;36(11):3127–3128.
29. Oliveira-Filho J, Ezzeddine MA, Segal AZ, et al. Fever in subarachnoid hemorrhage: relationship to vasospasm and outcome. Neurology. 2001;56(10):1299–1304.
30. Fernandez A, Schmidt JM, Claassen J, et al. Fever after subarachnoid hemorrhage: risk factors and impact on outcome. Neurology. 2007;68(13):1013–1019.
31. Castillo J, Davalos A, Marrugat J, Noya M. Timing for fever-related brain damage in acute ischemic stroke. Stroke. 1998;29(12):2455–2460.
32. Henry JA, Jeffreys KJ, Dawling S. Toxicity and deaths from 3,4-methylenedioxymethamphetamine (“ecstasy”). Lancet. 1992;340(8816):384–387.
33. Grieger TA, Kluger MJ. Fever and survival: the role of serum iron. J Physiol. 1978;279:187–196.
34. Kluger MJ, Kozak W, Conn CA, Leon LR, Soszynski D. The adaptive value of fever. Infect Dis Clin North Am. 1996;10(1):1–20.
35. Mackowiak PA, Marling-Cason M, Cohen RL. Effects of temperature on antimicrobial susceptibility of bacteria. J Infect Dis. 1982;145(4):550–553.
36. Schulman CI, Namias N, Doherty J, et al. The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study. Surg Infect (Larchmt). 2005;6(4):369–375.
37. Mackowiak PA, LeMaistre CF. Drug fever: a critical appraisal of conventional concepts. An analysis of 51 episodes in two Dallas hospitals and 97 episodes reported in the English literature. Ann Intern Med. 1987;106(5):728–733.
38. Roth J, Rummel C, Barth SW, Gerstberger R, Hubschle T. Molecular aspects of fever and hyperthermia. Immunol Allergy Clin North Am. 2009;29(2):229–245.
39. Henderson VW, Wooten GF. Neuroleptic malignant syndrome: a pathogenetic role for
dopamine receptor blockade?
Neurology. 1981;31(2):132–137.
40. Lawrence KR, Adra M, Gillman PK. Serotonin toxicity associated with the use of
linezolid: a review of postmarketing data.
Clin Infect Dis. 2006;42(11):1578–1583.
41. Mills EM, Banks ML, Sprague JE, Finkel T. Pharmacology: uncoupling the agony from ecstasy. Nature. 2003;426(6965):403–404.
42. Stocchetti N, Rossi S, Zanier ER, Colombo A, Beretta L, Citerio G. Pyrexia in head-injured patients admitted to intensive care. Intensive Care Med. 2002;28(11):1555–1562.
43. Zeiner A, Holzer M, Sterz F, et al. Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome. Arch Intern Med. 2001;161(16):2007–2012.
44. Diringer MN, Reaven NL, Funk SE, Uman GC. Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med. 2004;32(7):1489–1495.
45. Greer DM, Funk SE, Reaven NL, Ouzounelli M, Uman GC. Impact of fever on outcome in patients with stroke and neurologic injury: a comprehensive meta-analysis. Stroke. 2008;39(11):3029–3035.
46. Horowitz M, Robinson SD. Heat shock proteins and the heat shock response during hyperthermia and its modulation by altered physiological conditions. Prog Brain Res. 2007;162:433–446.
47. Commichau C, Scarmeas N, Mayer SA. Risk factors for fever in the neurologic intensive care unit. Neurology. 2003;60(5):837–841.
48. Powers JH, Scheld WM. Fever in neurologic diseases. Infect Dis Clin North Am. 1996;10(1):45–66.
49. Murray HW, Ellis GC, Blumenthal DS, Sos TA. Fever and pulmonary thromboembolism. Am J Med. 1979;67(2):232–235.
50. Diamond PT, Macciocchi SN. Predictive power of clinical symptoms in patients with presumptive deep venous thrombosis. Am J Phys Med Rehabil. 1997;76(1):49–51.
51. Kazmers A, Groehn H, Meeker C. Do patients with acute deep vein thrombosis have fever? Am Surg. 2000;66(6):598–601.
52. Laupland KB. Fever in the critically ill medical patient. Crit Care Med. 2009;37(7 suppl):S273–S278.
53. O'Grady NP, Barie PS, Bartlett JG, et al. Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med. 2008;36(4):1330–1349.
54. Cunha BA, Shea KW. Fever in the intensive care unit. Infect Dis Clin North Am. 1996;10(1):185–209.
55. Ringel AF, Jameson GL, Foster ES. Diarrhea in the intensive care patient. Crit Care Clin. 1995;11(2):465–477.
56. Zollner-Schwetz I, Hogenauer C, Joainig M, et al. Role of Klebsiella oxytoca in antibiotic-associated diarrhea. Clin Infect Dis. 2008 1;47(9):e74–e78.
57. Campbell GD Jr. Blinded invasive diagnostic procedures in ventilator-associated pneumonia. Chest. 2000;117(4 suppl 2):207S–211S.
58. Garibaldi RA, Brodine S, Matsumiya S, Coleman M. Evidence for the non-infectious etiology of early postoperative fever. Infect Control. 1985;6(7):273–277.
59. Bert F, Lambert-Zechovsky N. Microbiology of nosocomial sinusitis in intensive care unit patients. J Infect. 1995;31(1):5–8.
60. Shapiro GG, Rachelefsky GS. Introduction and definition of sinusitis. J Allergy Clin Immunol. 1992;90(3 pt 2):417–418.
61. van Zanten AR, Dixon JM, Nipshagen MD, de Bree R, Girbes AR, Polderman KH. Hospital-acquired sinusitis is a common cause of fever of unknown origin in orotracheally intubated critically ill patients. Crit Care. 2005;9(5):R583–R590.
62. Pneumatikos I, Konstantonis D, Tsagaris I, et al. Prevention of nosocomial maxillary sinusitis in the ICU: the effects of topically applied alpha-adrenergic agonists and corticosteroids. Intensive Care Med. 2006;32(4):532–537.
63. Cheadle WG. Current perspectives on antibiotic use in the treatment of surgical infections. Am J Surg. 1992;164(4A suppl):44S–47S.
64. Marik PE, Zaloga GP. Adrenal insufficiency in the critically ill: a new look at an old problem. Chest. 2002;122(5):1784–1796.
65. Manthous CA, Hall JB, Olson D, et al. Effect of cooling on
oxygen consumption in febrile critically ill patients.
Am J Respir Crit Care Med. 1995;151(1):10–14.
66. Bernard GR, Wheeler AP, Russell JA, et al. The effects of
ibuprofen on the physiology and survival of patients with sepsis. The
Ibuprofen in Sepsis Study Group.
N Engl J Med. 1997;336(13):912–918.
67. Plaisance KI, Mackowiak PA. Antipyretic therapy: physiologic rationale, diagnostic implications, and clinical consequences. Arch Intern Med. 2000;160(4):449–456.