Worldwide, dogs are the most commonly infected animal and the principal reservoir of disease. In the United States, due to high levels of veterinary care, the principal reservoirs are wild raccoons, skunks, foxes, and bats. In the United States, most human cases of rabies are associated with bats. Following a bite, domesticated animals that are apparently healthy should be observed for 10 days; if the animal does not show signs of rabies, then no treatment is required. However, wild animals that are caught should undergo autopsy and antibody testing immediately. Victims should undergo prophylaxis, which can later be discontinued, unless results are immediately available. Postexposure rabies prophylaxis should consist of localized wound care, passive immunization with human rabies immunoglobulin (HRIG), and active immunization with human diploid cell vaccine (HDCV). HRIG 20 U/kg should be administered into the immediate wound, as much as possible, with the remainder given IM. HDCV should be given IM at a distal site (deltoid) on days 0, 3, 7, 14, and 28 (Gluteal injections are discouraged, as the drug may be inadvertently deposited in subcutaneous tissues). Patients with previous prophylaxis do not need HRIG and should get HDCV on days 0 and 3 only. Prophylaxis may be given during pregnancy and does not result in an increase in fetal wastage, congenital defects, or side effects and should not be withheld when indicated. Corticosteroids, antimalarials, and other immunosuppressives can interfere with the development of active immunity and should be withheld during the course of treatment, if possible. In immunosuppressed patients, it may be necessary to have antibody titers checked at 2 and 4 weeks to ensure a response. Egg allergy is a concern in influenza prophylaxis, where the vaccine is nurtured in eggs, but there is no concern when giving rabies postexposure prophylaxis.