In adults, common causes of priapism include sickle cell anemia, spinal cord lesions, medications (SSRIs, phenothiazines, antihypertensives, anticoagulants, etc.), drugs of abuse, sexual arousal, intercavernosal injections for impotence, phenothiazines, and other medications. In children, the most common causes of priapism are sickle cell anemia and leukemia. Rarely, priapism can also be seen in Kawasaki disease. Priapism, a prolonged erection, results from the engorgement of the dorsal corpora cavernosa while the corpus spongiosum and glans remain soft. There are two types: low-flow priapism is typically painful and results from decreased venous outflow; high-flow priapism is typically painless and results from increased arterial inflow associated with a penile laceration. Initial management for all causes includes terbutaline 0.25 mg SQ in the deltoid, a dorsal penile nerve block for pain control, and a urologic consultation. If refractory, additional treatment options include corporal aspiration, heparin irrigation, injection with phentolamine, phenylephrine, ephedrine or epinephrine, exchange transfusion, or shunt surgery. To avoid long-term dysfunction, interventions should be initiated within 12 hours.