The anticholinergic poisoning syndrome can be remembered as: hot as a hare, blind as a bat, dry as a bone, red as a beet, mad as a hen. Clinically the anticholinergic poisoning syndrome presents with altered mental status, tachycardia, mydriasis, decreased bowel sounds, urinary retention, and dry axilla. The cholinergic poisoning syndrome can be remembered by the mnemonic SLUDGE (Salivation, Lacrimation, Urination, Defecation, GI hypermotility, and Emesis). The sympathomimetic syndrome includes tachycardia, hypertension, mydriasis, and diaphoresis. Urinary retention can also be found in the patient poisoned with sympathomimetics secondary to alpha-receptor agonism on the sphincter muscle of the bladder. Alpha2-receptor agonism essentially produces a sympatholytic syndrome. Clonidine and other imidazoles are alpha2-agonists that act presynaptically to inhibit sympathetic outflow from the CNS. Alpha2-agonists therefore produce miosis, bradycardia, and hypotension. Alpha2-agonist poisoning also produces a depressed mental status, respiratory depression, and coma. Alpha2-agonist poisoning can be confused with opiate poisoning. Opiate poisoning usually does not result in significant bradycardia or hypotension. Withdrawal syndrome produces insomnia, diarrhea, hallucinosis, tachycardia, diaphoresis, and hypertension.