The primary contraindication to injection of a Morton's neuroma is failure to make a correct initial diagnosis. The differential diagnosis for forefoot pain includes a wide variety of pathologies, many of which may closely mimic the presentation of a neuroma. Alternative diagnoses include tarsal tunnel syndrome, peripheral neuropathy, capsulitis, bursitis, rheumatoid arthritis, foreign bodies, avascular necrosis, stress fractures, and peripheral vascular insufficiency. A careful history and physical examination with discretionary use of imaging modalities will lead to a correct diagnosis.