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Despite exposure to wide fluctuations of environmental temperatures, human body temperature is maintained within a narrow range.16,120 Elevation or depression of body temperature occurs when (1) thermoregulatory mechanisms are overwhelmed by exposure to extremes of environmental heat or cold; (2) endogenous heat production is either inadequate, resulting in hypothermia, or exceeds the physiologic capacity for dissipation, resulting in hyperthermia; or (3) disease processes or xenobiotic effects interfere with normal thermoregulatory responses to heat or cold exposure.


Heat is transferred to or away from the body through radiation, conduction, convection, and evaporation. Radiation involves the transfer of heat from an object to the environment and from warm objects in the environment to another object, for example, from the sun to a body. Conduction involves the transfer of heat to solid or liquid media in direct contact with the body. Water immersion conducts significant amounts of heat away from the body. This effect facilitates cooling in a swimming pool on a hot summer day and hypothermia despite moderate ambient temperatures when an individual is wet on a rainy day. The amount of heat lost through conduction and radiation depends on the temperature gradient between the skin and its surroundings; cutaneous blood flow; and insulation such as subcutaneous fat, hair, clothing.134 In the respiratory tract, heat is lost by conduction to water vapor or gas. In animals unable to sweat, this represents the primary method of heat loss. The amount of heat lost through the respiratory tract depends on the temperature gradient between inspired air and the environment and the rate and depth of breathing.134 Convection is the transfer of heat to the air surrounding the body. Wind velocity and ambient air temperature are the major determinants of convective heat loss. Evaporation is the process of vaporization of water, such as that in sweat. Large amounts of heat are dissipated from the skin during this process, resulting in cooling. Ambient temperature, rate of sweating, air velocity, and relative humidity are important factors in determining how much heat is lost through evaporation. On a very hot and humid day, sweat pours off an exercising person, rather than evaporating and initiating heat loss. In very warm environments, thermal gradients are reversed, leading to transfer of heat to the body by radiation, conduction, or convection.143


In a human not affected by xenobiotics or disease, stimulation of peripheral and hypothalamic temperature-sensitive neurons results in autonomic, somatic, and behavioral responses that lead to the dissipation or conservation of heat. Thermoregulation is the complex physiologic process that serves to maintain hypothalamic temperature within a narrow range of 98.6 ± 0.8°F (37 ± 0.4°C), known as the set point.120 This hypothalamic set point is influenced by factors such as diurnal variation, the menstrual cycle, and others. Maintaining, raising, or lowering ...

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