TY - CHAP M1 - Book, Section TI - Clotting Disorders A1 - Nelson, Jessie G. A1 - Hemphill, Robin R. A2 - Tintinalli, Judith E. A2 - Stapczynski, J. Stephan A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Cline, David M. PY - 2016 T2 - Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e AB - Most patients who develop an arterial or venous thrombosis do so because of local factors (e.g., a focal atherosclerotic lesion producing a thrombus in an coronary artery) or major systemic events (e.g., trauma, surgery, or prolonged immobilization). However, several inherited genetic mutations predispose patients to venous thromboembolism with some studies finding up to 50% of patients with venous thromboembolism having a thrombophilia (Table 234-1).1 Importantly, risk for clotting from genetic, acquired, and environmental factors is additive or even multiplicative; a patient with mild deficiency may develop a deep venous thrombosis when started on estrogen.2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/12 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1121500709 ER -