TY  - CHAP
M1  - Book, Section
TI  - Clotting Disorders
A1  - Nelson, Jessie G.
A1  - Hemphill, Robin R.
A2  - Tintinalli, Judith E.
A2  - Stapczynski, J. Stephan
A2  - Ma, O. John
A2  - Yealy, Donald M.
A2  - Meckler, Garth D.
A2  - Cline, David M.
PY  - 2016
T2  - Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e
AB  - Most  patients  who  develop  an  arterial  or  venous  thrombosis  do  so  because  of  local  factors  (e.g.,  a  focal  atherosclerotic  lesion  producing  a  thrombus  in  an  coronary  artery)  or  major  systemic  events  (e.g.,  trauma,  surgery,  or  prolonged  immobilization).  However,  several  inherited  genetic  mutations  predispose  patients  to  venous  thromboembolism  with  some  studies  finding  up  to  50%  of  patients  with  venous  thromboembolism  having  a  thrombophilia  (Table  234-1).1  Importantly,  risk  for  clotting  from  genetic,  acquired,  and  environmental  factors  is  additive  or  even  multiplicative;  a  patient  with  mild  deficiency  may  develop  a  deep  venous  thrombosis  when  started  on  estrogen.2  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessemergencymedicine.mhmedical.com/content.aspx?aid=1121500709
ER  -