TY - CHAP M1 - Book, Section TI - Acetaminophen A1 - Hung, Oliver L. A1 - Nelson, Lewis S. A2 - Tintinalli, Judith E. A2 - Stapczynski, J. Stephan A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Cline, David M. PY - 2016 T2 - Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e AB - Acetaminophen (N-acetyl-p-aminophenol or paracetamol) is the most popular over-the-counter analgesic and is one of the most common toxic exposures reported to poison centers. Acetaminophen is available as a sole agent or combined with a variety of other medications prepared in many different forms, such as tablets, capsules, gels, and liquids. Poisonings often occur because of the erroneous belief that this medication is benign or because the victim was unaware that acetaminophen was an ingredient in the ingested preparation.1 The U.S. Acute Liver Failure Study Group found that acetaminophen poisoning was the cause of acute liver failure in 18% of cases initially judged to be of unknown cause.2 Acetaminophen–opioid combination products have been implicated in chronic overuse, likely due to an increasing opioid requirement leading to concomitantly increasing acetaminophen exposure. In response to these safety concerns, the U.S. Food and Drug Administration recently limited the prescription acetaminophen–opioid combination preparation strength to 325 milligrams per dosage unit and now requires a boxed warning to notify consumers of the potential risk for serious liver toxicity.3 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1121512929 ER -