TY - CHAP M1 - Book, Section TI - ADVERSE CUTANEOUS DRUG REACTIONS A1 - Wolff, Klaus A1 - Johnson, Richard Allen A1 - Saavedra, Arturo P. A1 - Roh, Ellen K. PY - 2017 T2 - Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology, 8e AB - Adverse cutaneous drug reactions (ACDRs) are unpredictable They affect 2 to 3% of inpatients and lead to 0.1 to 0.3% of hospital fatalities1.In the United States, adverse drug events account for up to 140,000 deaths and $136 billion in costs annually.Most reactions are mild, accompanied by pruritus, and resolve promptly after the offending drug is discontinued.Drug eruptions can mimic virtually all the morphologic expressions in dermatology and must be the first consideration in the differential diagnosis of a suddenly appearing eruption.Drug eruptions are caused by immunologic or nonimmunologic mechanisms and are provoked by systemic or topical administration of a drug.The majority are based on a hypersensitivity mechanism and are thus immunologic and may be of types I, II, III, or IV. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1140791889 ER -