TY  - CHAP
M1  - Book, Section
TI  - Diabetic Ketoacidosis
A1  - Nyce, Andrew
A1  - Byrne, Richard
A1  - Lubkin, Cary L.
A1  - Chansky, Michael E.
A2  - Tintinalli, Judith E.
A2  - Ma, O. John
A2  - Yealy, Donald M.
A2  - Meckler, Garth D.
A2  - Stapczynski, J. Stephan
A2  - Cline, David M.
A2  - Thomas, Stephen H.
PY  - 2020
T2  - Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e
AB  - Diabetic  ketoacidosis  (DKA)  is  an  acute,  life-threatening  complication  of  diabetes  mellitus.  DKA  occurs  predominantly  in  patients  with  type  1  (insulin-dependent)  diabetes  mellitus.  The  incidence  of  DKA  in  the  United  Kingdom,  United  States,  and  other  developed  countries  is  comparable,  with  an  annual  incidence  between  13.4  and  14.9  cases  per  1000  type  1  diabetics.1  There  has  been  an  increased  number  of  DKA  cases  in  patients  with  newly  diagnosed  type  2  (non–insulin-dependent)  diabetes  mellitus,  especially  in  African  Americans  and  Hispanics.  Ketosis-prone  type  2  diabetics  have  significant  impairment  in  insulin  secretion  and  action  that  subsequently  recovers  after  resolution  of  DKA.1  Over  the  past  decade  in  the  United  States,  the  frequency  of  DKA  has  increased  by  30%,  with  close  to  140,000  hospitalizations  per  year.2  A  better  understanding  of  the  pathophysiology  of  DKA  and  an  aggressive,  uniform  approach  to  its  diagnosis  and  management  have  reduced  mortality  to  <1%  of  reported  episodes  in  experienced  centers.1  However,  mortality  is  higher  in  patients  from  developing  countries,  those  with  comorbidities  and  the  elderly.3  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessemergencymedicine.mhmedical.com/content.aspx?aid=1182415678
ER  -