TY - CHAP M1 - Book, Section TI - Chapter 122. Edrophonium (Tensilon) Testing A1 - Reichman, Eric F. PY - 2013 T2 - Emergency Medicine Procedures, 2e AB - Myasthenia gravis is an autoimmune disorder that occurs when polyclonal antibodies bind to a significant number of postsynaptic acetylcholine receptors at the neuromuscular junction leading to inadequate neuromuscular transmission.1–3 It most commonly affects 10- to 30-year-old females and 70- to 90-year-old males. Multiple tests are available to diagnose myasthenia gravis.3–7 These include the use of muscle biopsies, curare, edrophonium chloride (Tensilon), electromyography, ice packs, neostigmine, nerve stimulation, and serologic testing. The edrophonium test is the most commonly used diagnostic test for myasthenia gravis.8–10 Many of these techniques are seldom used and not feasible to perform in the Emergency Department. For these reasons, only the edrophonium test and the ice pack test will be described in this chapter. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=57712830 ER -