TY - CHAP M1 - Book, Section TI - Acetaminophen Toxicity A1 - Lu, Jenny J. A2 - Sherman, Scott C. A2 - Weber, Joseph M. A2 - Schindlbeck, Michael A. A2 - Rahul G., Patwari PY - 2014 T2 - Clinical Emergency Medicine AB - Acetaminophen is the most popular over-the-counter analgesic in the United States and is widely prescribed in combination form with alternative pain relievers, resulting in frequent unintentional overdose.Treatment with N-acetylcysteine detoxifies NAPQI, the hepatotoxic byproduct of acetaminophen metabolism.The Rumack-Matthew nomogram should only be used in acute overdoses with reliable times of ingestion. Pay careful attention to all units of measurement.Consider early transfer to a liver transplant center for patients with worsening hepatic function or general signs of deterioration before they meet criteria for liver transplantation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1101225847 ER -