TY - CHAP M1 - Book, Section TI - Antidotes in Depth A1 - Howland, Mary Ann A2 - Hoffman, Robert S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Nelson, Lewis S. A2 - Goldfrank, Lewis R. PY - 2015 T2 - Goldfrank's Toxicologic Emergencies, 10e AB - Protamine is a rapidly acting antidote that is used primarily to reverse the anticoagulant effects of unfractionated heparin (UFH). It neutralizes the anti-IIa activity of low-molecular-weight heparin (LMWH) and incompletely neutralizes the anti-Xa activity of LMWH, which may normalize activated partial thromboplastin time (aPTT) and the thrombin time, but variably resolves clinical bleeding. Protamine has no effect on heparin pentasaccharide fragments or analogs such as fondaparinux. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1108422090 ER -