TY  - CHAP
M1  - Book, Section
TI  - Antiepileptics
A1  - Doyon, Suzanne
A2  - Hoffman, Robert S.
A2  - Howland, Mary Ann
A2  - Lewin, Neal A.
A2  - Nelson, Lewis S.
A2  - Goldfrank, Lewis R.
PY  - 2015
T2  - Goldfrank's Toxicologic Emergencies, 10e
AB  - Historically,  seizures  were  treated  by  a  variety  of  methods,  including  ketogenic  diets,  fluid  restriction,  and  surgical  excision  of  scars  or  irritable  ­cortical  foci.  The  first  truly  effective  antiepileptic  therapy  was  introduced  in  1857,  when  the  administration  of  bromides  was  noted  to  sedate  patients  and  significantly  reduce  their  seizures.  Phenobarbital,  a  sedative–hypnotic,  was  first  used  to  treat  seizures  in  1912.  Most  of  the  subsequently  introduced  antiepileptics  such  as  primidone  had  chemical  structures  similar  to  that  of  phenobarbital,  and  sedation  was  erroneously  believed  to  be  an  essential  component  of  antiepileptic  therapy.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessemergencymedicine.mhmedical.com/content.aspx?aid=1108439395
ER  -