TY - CHAP M1 - Book, Section TI - Nonsteroidal Anti-Inflammatory Drugs A1 - Rella, Joseph G. A1 - Carter, Wallace A. A2 - Tintinalli, Judith E. A2 - Stapczynski, J. Stephan A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Cline, David M. Y1 - 2016 N1 - T2 - Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used class of drugs in the United States, and all share inhibition of the cyclooxygenase enzyme as a mechanism of action. NSAIDs are effective antipyretics, analgesics, and anti-inflammatory agents. Because of their large therapeutic window, acute ingestion with overdoses rarely produces serious complications.1,2 The morbidity from NSAIDs in acute overdose is far overshadowed by complications of NSAIDs at therapeutic doses, which include GI bleeding, drug-induced renal failure, and atherosclerotic heart disease.3,4,5,6 Due to their increased risk for cardiovascular disease, rofecoxib and valdecoxib were withdrawn from the U.S. market in 2004 and 2005, respectively. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1121499880 ER -