TY - CHAP M1 - Book, Section TI - Diabetic Ketoacidosis A1 - Nyce, Andrew A1 - Byrne, Richard A1 - Lubkin, Cary L. A1 - Chansky, Michael E. A2 - Tintinalli, Judith E. A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Stapczynski, J. Stephan A2 - Cline, David M. A2 - Thomas, Stephen H. Y1 - 2020 N1 - T2 - Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e AB - Diabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus. DKA occurs predominantly in patients with type 1 (insulin-dependent) diabetes mellitus. The incidence of DKA in the United Kingdom, United States, and other developed countries is comparable, with an annual incidence between 13.4 and 14.9 cases per 1000 type 1 diabetics.1 There has been an increased number of DKA cases in patients with newly diagnosed type 2 (non–insulin-dependent) diabetes mellitus, especially in African Americans and Hispanics. Ketosis-prone type 2 diabetics have significant impairment in insulin secretion and action that subsequently recovers after resolution of DKA.1 Over the past decade in the United States, the frequency of DKA has increased by 30%, with close to 140,000 hospitalizations per year.2 A better understanding of the pathophysiology of DKA and an aggressive, uniform approach to its diagnosis and management have reduced mortality to <1% of reported episodes in experienced centers.1 However, mortality is higher in patients from developing countries, those with comorbidities and the elderly.3 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/06 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1182415678 ER -