TY  - CHAP
M1  - Book, Section
TI  - Cannabinoids
A1  - Lapoint, Jeff M.
A2  - Nelson, Lewis S.
A2  - Howland, Mary Ann
A2  - Lewin, Neal A.
A2  - Smith, Silas W.
A2  - Goldfrank, Lewis R.
A2  - Hoffman, Robert S.
Y1  - 2019
N1  - 
T2  - Goldfrank's Toxicologic Emergencies, 11e
AB  - Cannabis  has  been  used  for  more  than  4,000  years.  The  earliest  documentation  of  the  therapeutic  use  of  marijuana  is  the  fourth  century  B.C.  in  China.172  Cannabis  use  spread  from  China  to  India  to  North  Africa,  reaching  Europe  around  A.D.  500.138  In  colonial  North  America,  cannabis  was  cultivated  as  a  source  of  fiber.  Similar  to  cocaine  and  morphine,  cannabis  was  the  focus  of  research  efforts  in  the  19th  century.  Although  the  active  chemical  constituents  of  the  former  were  isolated  during  this  time,  that  of  cannabis  remained  elusive.97  This  was  because  the  active  compounds  of  opium  poppy  and  coca  leaf  are  both  alkaloids  and  were  possible  to  extract  with  the  technological  means  of  the  time,  whereas  the  methods  to  isolate  the  active  terpenes  in  cannabis  were  not  available  to  researchers  until  several  decades  later.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - accessemergencymedicine.mhmedical.com/content.aspx?aid=1163018123
ER  -