TY - CHAP M1 - Book, Section TI - Arterial Occlusion A1 - Carr, David A1 - Nowacki, Anna K. A2 - Tintinalli, Judith E. A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Stapczynski, J. Stephan A2 - Cline, David M. A2 - Thomas, Stephen H. Y1 - 2020 N1 - T2 - Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e AB - Limb ischemia occurs when blood flow—and by extension, tissue perfusion—is limited enough to create symptoms; acute limb ischemia denotes rapid new event or a progression of a flow deficit, requiring recognition and rapid therapy for limb salvage. Critical limb ischemia is one end of the spectrum of peripheral arterial disease, when pain at rest, ulceration, or gangrene exists. Smoking and diabetes are the most important risk factors for peripheral arterial disease.1 Additional risk factors include hyperlipidemia, hypertension, elevated blood homocysteine, and an elevated C-reactive protein level.2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2023/03/30 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1166532418 ER -