TY - CHAP M1 - Book, Section TI - Adverse Cutaneous Drug Reactions A1 - Saavedra, Arturo P. A1 - Roh, Ellen K. A1 - Mikailov, Anar Y1 - 2023 N1 - T2 - Fitzpatrick’s Color Atlas and Synopsis of Clinical Dermatology, 9e AB - Adverse cutaneous drug reactions (ACDRs) are unpredictable1. They affect 2% to 3% of inpatients and lead to 0.1% to 0.3% of hospital fatalities.In the United States, adverse drug events account for up to 140,000 deaths and $136 billion in costs annually.Most reactions are mild, accompanied by pruritus, and resolve promptly after the offending drug is discontinued.Drug eruptions can mimic virtually all the morphologic expressions in dermatology and must be the first consideration in the differential diagnosis of a suddenly appearing eruption.Drug eruptions are caused by immunologic or nonimmunologic mechanisms and are provoked by systemic or topical administration of a drug.The majority are based on a hypersensitivity mechanism and are thus immunologic and may be of types I, II, III, or IV. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1199571458 ER -