TY - CHAP M1 - Book, Section TI - Chapter 48. Jaundice, Hepatic Disorders, and Hepatic Failure A1 - Gentges, Joshua A2 - Cline, David M. A2 - Ma, O. John A2 - Cydulka, Rita K. A2 - Meckler, Garth D. A2 - Handel, Daniel A. A2 - Thomas, Stephen H. Y1 - 2012 N1 - T2 - Tintinalli's Emergency Medicine Manual, 7e AB - Jaundice, a yellowish discoloration of the skin, sclerae, and mucous membranes, results from hyperbilirubinemia (breakdown of hemoglobin) and the deposition of bile pigments. Etiologies include disorders of bilirubin metabolism (eg, hemolysis) and hepatocellular causes due to infections, drugs and toxins, metabolic disease, granulomatous disease, and bile duct obstruction. Hyperbilirubinemia can be divided into 2 types. The unconjugated form results from increased bilirubin production or a liver defect in its uptake or conjugation. The conjugated form occurs in the setting of intra- or extrahepatic cholestasis, resulting in decreased excretion of conjugated bilirubin. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=56273162 ER -