TY - CHAP M1 - Book, Section TI - Cyclic Antidepressants A1 - Karydes, Harry C. A2 - Sherman, Scott C. A2 - Weber, Joseph M. A2 - Schindlbeck, Michael A. A2 - Rahul G., Patwari Y1 - 2014 N1 - T2 - Clinical Emergency Medicine AB - Cyclic antidepressants remain a leading cause of poisoning-related fatalities among psychoactive medications.Patients will frequently present with minimal signs and symptoms only to abruptly decompensate from life-threatening cardiovascular and central nervous system toxicity.Cardiovascular toxicity (specifically refractory hypotension) is the leading cause of morbidity and mortality in cyclic antidepressant overdose.Hypertonic sodium bicarbonate should be given in 1–2 mEq/kg boluses to reverse the wide-complex dysrhythmias commonly encountered with cyclic antidepressant poisoning. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1101225994 ER -