TY - CHAP M1 - Book, Section TI - Pharmacokinetic and Toxicokinetic Principles A1 - Howland, Mary Ann A2 - Hoffman, Robert S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Nelson, Lewis S. A2 - Goldfrank, Lewis R. Y1 - 2015 N1 - T2 - Goldfrank's Toxicologic Emergencies, 10e AB - Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of xenobiotics. Xenobiotics are substances that are foreign to the body and include natural or synthetic chemicals, drugs, pesticides, environmental agents, and industrial agents.49 Mathematical models and equations are used to describe and to predict these phenomena. Pharmacodynamics is the term used to describe an investigation of the relationship of xenobiotic concentration to clinical effects. Toxicokinetics, which is analogous to pharmacokinetics, is the study of the absorption, distribution, metabolism, and excretion of a xenobiotic under circumstances that produce toxicity. Toxicodynamics, which is analogous to pharmacodynamics, is the study of the relationship of toxic concentrations of xenobiotics to clinical effects. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1108424482 ER -