TY - CHAP M1 - Book, Section TI - Insecticides: Organic Phosphorus Compounds and Carbamates A1 - Eddleston, Michael A2 - Hoffman, Robert S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Nelson, Lewis S. A2 - Goldfrank, Lewis R. Y1 - 2015 N1 - T2 - Goldfrank's Toxicologic Emergencies, 10e AB - The first potent synthetic organic phosphorus anticholinesterase, tetraethylpyrophosphate (TEPP), was synthesized by Clermont in 1854. Clermont’s report described the taste of the compound, a remarkable achievement because a few drops should be rapidly fatal.111 In 1932, Lange and Krueger wrote of choking and blurred vision following inhalation of dimethyl and diethyl phosphorofluoridates. This account inspired Schrader in Germany to begin investigating these agents, initially as pesticides, and later for use in warfare (Chap. 132). During this research, Schrader’s group synthesized hundreds of compounds, including the popular pesticide parathion and the chemical weapons sarin, soman, and tabun. Allied scientists were also motivated during the same period by the work and independently discovered other extremely toxic compounds such as diisopropylphosphofluoridate (DFP).214 Since that time, it is estimated that more than 50,000 organic phosphorus compounds have been synthesized and screened for pesticidal activity, with dozens being produced commercially.40 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1108435876 ER -