TY - CHAP M1 - Book, Section TI - Clostridium Difficile Infection A1 - Franco, Alexandra A1 - Mazuski, John E. A1 - Eaton, Stephen R. A1 - Husain, Kareem D. A1 - Tuda, Claudio A2 - Farcy, David A. A2 - Chiu, William C. A2 - Marshall, John P. A2 - Osborn, Tiffany M. PY - 2016 T2 - Critical Care Emergency Medicine, 2e AB - Clostridium difficile Infection (CDI) is the most common cause of infectious nosocomial diarrhea in adults in developed countries. Currently, it is considered an important transmissible nosocomial disease causes often appear in outbreaks within healthcare facilities. Prior to 1977, the clostridial disease most commonly described was a form of skin and soft-tissue gangrene caused by a strain named Clostridium perfringens, with fatal outcomes often reported. Once the antibiotic era started, an antibiotic-associated colitis was first described in animal models caused by Clostridium difficile (C. difficile). Shortly after, C. difficile associated colitis became the most common clostridial infection among humans in the hospital setting.1–4 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/23 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1135703150 ER -