TY - CHAP M1 - Book, Section TI - Intrathecal Administration of Xenobiotics A1 - Rao, Rama B. A2 - Nelson, Lewis S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Smith, Silas W. A2 - Goldfrank, Lewis R. A2 - Hoffman, Robert S. PY - 2019 T2 - Goldfrank's Toxicologic Emergencies, 11e AB - Cerebrospinal fluid (CSF) is produced by the choroid plexus that lines the cerebral ventricles at a rate of 15 to 30 mL/h, or approximately 500 mL/day in adults.57 Cerebrospinal fluid flows in a rostral to caudal direction and is reabsorbed through the arachnoid villi directly into the venous circulation. The estimated total volume of CSF is 130 to 150 mL in healthy adults and 35 mL in infants.57,74,99 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1163022475 ER -