TY - CHAP M1 - Book, Section TI - Acetaminophen A1 - Wightman, Rachel S. A1 - Nelson, Lewis S. A2 - Tintinalli, Judith E. A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Stapczynski, J. Stephan A2 - Cline, David M. A2 - Thomas, Stephen H. PY - 2020 T2 - Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e AB - Acetaminophen (N-acetyl-p-aminophenol or paracetamol) is the most popular over-the-counter analgesic and is one of the most common toxic exposures reported to poison centers. Acetaminophen (sometimes abbreviated APAP) is available as a sole agent or combined with a variety of other medications prepared in different forms, such as tablets, ­capsules, gels, and liquids. Although most serious poisonings involve intentional self-harm, poisonings often occur because of the erroneous belief that this medication is benign or because the victim was unaware that acetaminophen was an ingredient in the ingested preparation.1,2 In the United States, acetaminophen is the most common cause of drug-induced liver failure and accounts for almost half of all cases of acute liver failure.3,4 Acetaminophen–opioid combination products have been implicated in chronic overuse, likely due to an increasing opioid requirement leading to concomitantly increasing acetaminophen exposure.5 In response to these safety concerns, in 2011, the U.S. Food and Drug Administration limited the prescription acetaminophen–opioid combination preparation strength to 325 milligrams per dosage unit and now requires a boxed warning to notify consumers of the potential risk for serious liver toxicity.6 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1166600547 ER -