TY - CHAP M1 - Book, Section TI - Anticoagulants A1 - Williams, Saralyn R. A1 - Thurman, R. Jason A2 - Knoop, Kevin J. A2 - Stack, Lawrence B. A2 - Storrow, Alan B. A2 - Thurman, R. Jason PY - 2021 T2 - The Atlas of Emergency Medicine, 5e AB - Since the discovery of the cause of a hemorrhagic disorder in Wisconsin cattle in the early 20th century, warfarin and its analogs have been used as rodenticides and pharmacologic agents. Warfarin is actually named after the Wisconsin Alumni Research Foundation. Warfarin-like xenobiotics inhibit the activity of vitamin K 2,3-epoxide reductase, thus affecting the production of the vitamin K–dependent factors of II, VII, IX, and X. While the effect on the production of the vitamin K–dependent factors occurs soon after absorption of warfarin, the clinical effect is delayed until the available activated factors are depleted. SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/28 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1181056948 ER -